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KMID : 1009020210190040789
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Clinical Psychopharmacology and Neuroscience
2021 Volume.19 No. 4 p.789 ~ p.792
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Acute Hepatitis Due to Agomelatine Use in Elderly Women with Depression: Case Series
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Chang Cheng-Chen
Chen Yen-Jen
Chen Yu-An
Liao Yi-Cheng
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Abstract
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Although agomelatine may be associated with an increased risk of hepatotoxicity, the incidence rate of acute hepatitis seemed divergent between clinical trials and daily practice. Whether aging or gender is a risk factor in developing hepatotoxicity due to agomelatine is not clear. We present 3 older female cases with acute hepatitis occurring due to highly probable idiosyncratic drug-induced liver injury caused by agomelatine. From these cases, regular surveillance on liver function in the older women taking antidepressants would be of benefits.
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KEYWORD
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Agomelatine, Acute hepatitis, Major depression
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